Haruo Shintaku Selected Research

sapropterin (tetrahydrobiopterin)

1/2021	Guide for diagnosis and treatment of hyperphenylalaninemia.
12/2014	Sapropterin is safe and effective in patients less than 4-years-old with BH4-responsive phenylalanine hydrolase deficiency.
3/2014	Early replacement therapy in a first Japanese case with autosomal recessive guanosine triphosphate cyclohydrolase I deficiency with a novel point mutation.
1/2014	Clinical characteristics of epileptic seizures in a case of dihydropteridine reductase deficiency.
5/2013	Long-term follow-up of tetrahydrobiopterin therapy in patients with tetrahydrobiopterin deficiency in Japan.
12/2008	Diagnosis of tetrahydrobiopterin (BH4) responsive mild phenylketonuria in Japan over the past 10 years.
1/2008	Biopterin in the acute phase of hypoxia-ischemia in a neonatal pig model.
1/2008	A case of 6-pyruvoyl-tetrahydropterin synthase deficiency demonstrates a more significant correlation of L-Dopa dosage with serum prolactin levels than CSF homovanillic acid levels.
12/2007	Novel mechanism and role of angiotensin II induced vascular endothelial injury in hypertensive diastolic heart failure.
5/2007	Early initiation of L-dopa therapy enables stable development of executive function in tetrahydrobiopterin (BH4) deficiency.

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Haruo Shintaku Research Topics

Disease

11	Phenylketonurias (Phenylketonuria) 01/2021 - 05/2007
3	Mucopolysaccharidosis II (Hunter Syndrome) 06/2021 - 10/2017
3	Mucopolysaccharidoses 03/2020 - 01/2016
3	Intellectual Disability (Idiocy) 11/2019 - 05/2013
3	Hypothermia 01/2018 - 01/2008
2	Nervous System Diseases (Neurological Disorders) 12/2022 - 08/2017
2	Stroke (Strokes) 12/2020 - 01/2018
2	Infarction (Infarctions) 12/2020 - 01/2018
2	Brain Diseases (Brain Disorder) 12/2020 - 08/2017
2	Fever (Fevers) 01/2020 - 12/2017
2	Human Influenza (Influenza) 01/2020 - 12/2017
2	Menkes Kinky Hair Syndrome (Menkes Disease) 11/2018 - 05/2014
2	Brain Hypoxia-Ischemia (Hypoxia Ischemia, Brain) 01/2018 - 04/2013
2	Ischemia 01/2018 - 01/2008
2	Fibrosis (Cirrhosis) 01/2017 - 11/2016
2	Ketosis 12/2016 - 12/2004
2	Hypothyroidism 12/2016 - 06/2014
2	Lung Diseases (Lung Disease) 11/2016 - 01/2014
2	B BH4-Deficient Hyperphenylalaninemia 03/2014 - 01/2009
2	Hypertension (High Blood Pressure) 01/2014 - 12/2007
2	Inborn Genetic Diseases (Disease, Hereditary) 09/2012 - 05/2007
2	Hyperammonemia 06/2011 - 01/2007
2	Dopa-responsive Dystonia 11/2009 - 01/2009
1	Maternal Phenylketonuria 01/2021
1	Autoimmune Polyendocrinopathies (Schmidt Syndrome) 01/2021
1	Demyelinating Diseases (Demyelinating Disease) 01/2021
1	Autoimmune Diseases of the Nervous System 01/2021
1	Spasm (Spasms) 01/2021
1	Diabetes Mellitus 01/2021
1	Anti-N-Methyl-D-Aspartate Receptor Encephalitis 01/2021
1	Infantile Spasms (West Syndrome) 01/2021
1	Lysosomal Storage Diseases (Lysosomal Storage Disease) 11/2019
1	Respiratory Sounds (Crackle) 01/2019
1	Asthma (Bronchial Asthma) 01/2019
1	Cerebral Palsy (Spastic Diplegia) 01/2018
1	Neuronal Ceroid-Lipofuscinoses (Neuronal Ceroid Lipofuscinosis) 01/2018
1	Brain Injuries (Brain Injury) 01/2018
1	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/2018
1	Infections 12/2017
1	Graft vs Host Disease (Graft-Versus-Host Disease) 10/2017
1	Metabolic Diseases (Metabolic Disease) 09/2017
1	Adrenoleukodystrophy (Adrenoleukodystrophy, X-Linked) 09/2017
1	Opitz-Kaveggia syndrome 08/2017
1	Autism Spectrum Disorder 08/2017
1	Mental Retardation And Microcephaly With Pontine And Cerebellar Hypoplasia 08/2017
1	Microcephaly 08/2017
1	Death (Near-Death Experience) 01/2017
1	Chorioamnionitis 01/2017
1	Pneumonia (Pneumonitis) 01/2017

Drug/Important Bio-Agent (IBA)

10	sapropterin (tetrahydrobiopterin)FDA Link 01/2021 - 05/2007
5	Phenylalanine (L-Phenylalanine)FDA Link 01/2021 - 12/2008
4	BiopterinsIBA 01/2019 - 01/2008
4	Neurotransmitter Agents (Neurotransmitter)IBA 01/2018 - 01/2009
3	Phenylalanine Hydroxylase (Phenylalanine 4 Monooxygenase)IBA 01/2021 - 12/2014
3	GlycosaminoglycansIBA 03/2020 - 01/2017
3	EnzymesIBA 01/2018 - 08/2003
3	Insulin (Novolin)FDA Link 11/2016 - 06/2012
3	Serotonin (5 Hydroxytryptamine)IBA 03/2014 - 05/2007
3	Dopamine (Intropin)FDA LinkGeneric 03/2014 - 01/2008
3	Levodopa (L Dopa)FDA LinkGeneric 01/2014 - 05/2007
2	Glutamic Acid (Glutamate)FDA Link 12/2020 - 01/2018
2	Neuraminidase (Sialidase)IBA 01/2020 - 12/2017
2	Pharmaceutical PreparationsIBA 01/2020 - 12/2017
2	Biomarkers (Surrogate Marker)IBA 01/2019 - 09/2017
2	PteridinesIBA 01/2019 - 01/2009
2	CopperIBA 11/2018 - 05/2014
2	Disulfiram (Antabuse)FDA Link 11/2018 - 05/2014
2	CalciumIBA 08/2017 - 01/2014
2	Thyroxine (Levothyroxine)FDA LinkGeneric 12/2016 - 06/2014
2	GlucocorticoidsIBA 11/2016 - 01/2014
2	CytokinesIBA 12/2015 - 01/2007
1	idursulfase FDA Link 06/2021
1	Coenzymes (Enzyme Cofactors)IBA 01/2021
1	Oligoclonal BandsIBA 01/2021
1	Rituximab (Mabthera)FDA Link 01/2021
1	Monoclonal AntibodiesIBA 01/2021
1	Methylprednisolone FDA LinkGeneric 01/2021
1	Carnitine (L-Carnitine)FDA LinkGeneric 12/2020
1	baloxavirIBA 01/2020
1	Antiviral Agents (Antivirals)IBA 01/2020
1	Lysergic Acid Diethylamide (LSD)IBA 11/2019
1	Chloroquine (Aralen)FDA LinkGeneric 11/2019
1	Proteins (Proteins, Gene)FDA Link 11/2018
1	laninamivirIBA 12/2017
1	peramivirIBA 12/2017
1	Fatty Acids (Saturated Fatty Acids)IBA 09/2017
1	Lysophosphatidylcholines (Lysophosphatidylcholine)IBA 09/2017
1	Protein Kinases (Protein Kinase)IBA 08/2017
1	Serine (L-Serine)FDA Link 08/2017
1	Calmodulin (Calcium-Dependent Activator Protein)IBA 08/2017
1	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2017

Therapy/Procedure

12	Therapeutics 12/2022 - 05/2007
2	Enzyme Replacement Therapy 06/2021 - 11/2019
2	Cell- and Tissue-Based Therapy (Cell Therapy) 12/2020 - 01/2018
2	Surgical Portasystemic Shunt (Portosystemic Shunt) 12/2014 - 05/2014
1	Lasers (Laser) 12/2020
1	Intravenous Administration 01/2018
1	Resuscitation 01/2018
1	Hematopoietic Stem Cell Transplantation 10/2017
1	Transplantation 10/2017